Cumulative Risk Assessment Methods for Consideration3.1 Hazard Index Method3.2 Margin of Exposure Method3.3 Relative Potency Factor Method4. Proposed Approach for Considering Cumulative Effects of Phthalates in a Human Health Risk Assessment4.1 Selection Considerations for Inclusion of Phthalates in a Human Health Cumulative Risk Assessment4.1.1 Mode of Action4.1.2 Substance group Category definition4.1.3 Considerations for Addressing Data Gaps4.1.4 Hazard Filter4.1.5 Exposure Filter4.2 Proposed Approach for Human Health Cumulative Risk Assessment4.3 Hazard Characterization Considerations4.3.1 Selection of Endpoints4.3.2 Point of Departure Selection4.4 Exposure Characterization Considerations4.5 Uncertainties of the Health Approach5. Proposed Approach for Considering Cumulative Effects of Phthalates in an Ecological Risk Assessment5.1 Criteria for considering a cumulative ecological risk assessment5.2 Rationale for conducting a cumulative risk assessment of phthalates5.2.1 Modes of action for ecotoxicity of phthalates5.2.2 Potential for co occurrence of phthalates in the environment5.3 Methods considered for cumulative ecological risk assessment of phthalates5.3.1 PEC/PNEC Method5.3.2 Toxic Unit Summation5.3.3 Sum of Internal Toxic Units5.4 Proposed approach for cumulative ecological risk assessment of phthalates5.4.1 Selection of Substances5.4.2 Selection of Exposure Concentrations5.4.3 Selection of Bioaccumulation Factors5.4.4 Reaching a Conclusion on the Cumulative Ecological Risk of Certain Phthalates5.5 Uncertainties of the Ecological Approach6.
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